The Voomote One is a lil device that you plug your iPhone into, turning into a highly functional universal remote. You'll either never lose the remote again or will freak out a lot more when you do lose it.
When plugged in and with the free iPhone app working, the Voomote One lets you create your own button layout, set up different layouts for different rooms, and create complicated macros to turn multiple things on at once.
Of course, it also will ensure that no one is able to turn the TV on when you aren't home and your iPhone is in your pocket. And $99 is pretty pricey for a universal remote. But hey, if you live alone and want to be real fancy about how you change the channel, here you go.