Here's some exciting news: Harvard researcher Ronald A. DePhinho has discovered a way to reverse age degeneration in mice, opening the door to the possibility of a similar process working on humans.
The breakthrough revolves around the enzyme telomerase, which adds DNA sequence repeats at the end of chromosomes. Here's what they did with the mice:
We wanted to know: If you could flip the telomerase switch on and restore telomeres in animals with entrenched age-related disease, what would happen? Would it slow down aging, stabilize it, or even reverse it?If the effects are similar in humans, this could be a cure for diseases such as Alzheimer's as well as a way to look sexy when you're 80. Where do I sign up?
It was akin to a Ponce de León [the Spanish explorer looking for the Fountain of Youth] effect. When we flipped the telomerase switch on and looked a month later, the brains had largely returned to normal.
One of the most amazing changes was in the animals' testes, which were essentially barren as aging caused the death and elimination of sperm cells. When we restored telomerase, the testes produced new sperm cells, and the animals' fecundity was improved - their mates gave birth to larger litters.