The G50 Vanguard is a concept design for a mouse that is shaped like a hand. You know, to fit your hand. It's kind of a wonder that this seems so strange compared to a normal mouse.
I mean, doesn't this look comfortable? It's designed to fit your entire hand rather than just an object your hand can fit over. It also raises your hand off the table and reduces wrist anchoring and finger clamping, which all cause Carpal Tunnel.
Of course, if the Magic Trackpad is any indication, mice aren't long for this world, so this design might be too little, too late.
Via Yanko Design