Video: Awesome Krebs Cycle rap set to pop song tune

Teachers are always trying to set things to music so they're easier to remember (did you ever listen to this little gem in chemistry class?). But University of Ottawa students taking a general intermediary metabolism course were tasked with creating a song of their own about the TCA (Krebs) Cycle. We're loving this parody of Macklemore's "Thrift Shop" by the very talented Wilson Lam.

Here are the lyrics:

I'm gonna pop some carbs
Only got a lil' glucose in my pathway
I - I - I'm lazy, lookin' for some CoA
This is frigging awesome

Now I got some glucose; hell yeah, I'm in that prep phase
I'm so pumped; doin' work with hexokinase
Glucose to the glucose with a number six phosphate
PGI to that fructose 6-phosphate (dayum)
ATP, ADP, phosphofructokinase E,
1,6-bis, FBP, adolase, two GAP;
GAPDH with some PGK & PGM,
3-P to the 2-Phosphoglycerate, and then
PEP to Pyruvate! (glycolysis)

FAD, NAD bout to go and grab some hydroG
Pumpin' out all those substrates for some work yeah that's that energy
shuttlin' through that mito-C like nobody's business
what you know about oxidation? biz-NITCH
I'mma do it TCA, I'mma do it TCA
No for real - movin' on - can I have some A-CoA? (thank-you)
Citrate synthase from that CoA to that citrate
Aconitase, step two; isocitrate
I had some NAD+ (plus), I used some NAD+ (plus)
I made some NADH (Hhhhhhhh), and alpha-ketogluterate (oh snap)
dehydrogenase complex, plus some CoA
CO2, NADH out; succinyl CoA
then I take that GDP, add a P (GTP), hold on wait
CoAs gone, people be like "Aw, he got the succinate"

What you know about intermediary metabolism? (not much)
What you knowin' about what's goin' on in your skin? (uhhhhh)
I'm diggin, I'm diggin, I'm lookin' for some FAD
Step 6, succinate dehydrogenase, that's the key (zing)
Movin' on, reducin' that FAD up to FADH2
fumarate, fumarase that's the enzyme now go shift your gaze
to malate (okay); step 8, malate dehydrogenase
finish off; NADH, oxaloacetate (ahhhhh)

That's how Kreb's cycle goes
If you didn't doze now you know
This is how TCA flows
BCH actually doesn't blow


Don't miss Wilson Lam's video below. Hey, you might even learn something about how living cells generate energy.

YouTube, via io9

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